Biological Nitrogen Removal Database

A manually curated data resource for microbial nitrogen removal


Detailed description of the enzyme

Enzyme name Ntrite reductase (cytochrome c-552)
Synonyms cytochrome c-552;
octahaem cytochrome c nitrite reductase;
cytochrome c nitrite reductase complex;
NiR cytochrome c552;
nitrite reductase;
cytochrome c nitrite reductase;
NrfHA;
ccNiR;
pentaheme nitrite reductase;
octaheme nitrite reductase
Gene cluster nrfABCDEFG
Classification Oxidoreductases
Genes nrfA
Pathway Nitrogen metabolism: DNRA: Nitrite reduction (dissimilatory)
Substrate Nitrite 
Ferrocytochrome c 
Hydron
Product Nitrite;Ferricytochrome c;Hydron
Mechanism Link
Subunit
Gene
Protein name
Organism
Status
Accession Number (Genbank)
Accession Number (GenPept)
Accession Number (UniProt)
nrfA
Cytochrome c nitrite reductase
Desulfovibrio vulgaris str. Hildenborough
Reviewed
AJ697975.1 
CAG27083.1
Q72EF3
Reference

Authors

Title

PubMed ID

Full research link

Simon et al., 2002

A NapC/NirT-type cytochrome c (NrfH) is the mediator between the quinone pool and the cytochrome c nitrite reductase of Wolinella succinogenes

10672190

Link

Authors

Title


PubMed ID

Full research link

Einsle. 2011

Chapter Sixteen - Structure and Function of Formate-Dependent Cytochrome c Nitrite Reductase, NrfA

21514473

Link

Authors

Title


PubMed ID

Full research link

Bykov and Neese. 2015

Six-Electron Reduction of Nitrite to Ammonia by Cytochrome c Nitrite Reductase: Insights from Density Functional Theory Studies

26237518

Link

Authors

Title


PubMed ID

Full research link

Einsle et al., 1999

Structure of cytochrome c nitrite reductase

10440380

Link

Authors

Title


PubMed ID

Full research link

Shahid et al., 2021

A Kinetic Investigation of the Early Steps in Cytochrome c Nitrite Reductase (ccNiR)-Catalyzed Reduction of Nitrite

34143605

Link

Authors

Title


PubMed ID

Full research link

Mohan et al., 2004

Detection and widespread distribution of the nrfA gene encoding nitrite reduction to ammonia, a short circuit in the biological nitrogen cycle that competes with denitrification

19712292

Link

Authors

Title


PubMed ID

Full research link

Campeciño et al., 2020

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

32518164

Link