Biological Nitrogen Removal Database

A manually curated data resource for microbial nitrogen removal

Detailed description of the enzyme

Enzyme name	Hydrazine oxidoreductase
Synonyms	Hydroxylamine oxidase; HAO; Hydroxylamine oxidoreductase; Hydroxylamine-cytochrome c reductase; Hydroxylamine cytochrome c554 oxidoreductase; haoA
Gene cluster	haoAB
Classification	Oxidoreductases
Genes	haoA, haoB
Pathway	Nitrogen metabolism: Nitrification: Hydroxylamine oxidation
Substrate	Hydroxylamine Ferricytochrome c Water
Product	Nitrite Ferrocytochrome c Hydron Nitric oxide
Mechanism	Link
Subunit
Gene Protein name Organism Status Accession Number (Genbank) Accession Number (GenPept) Accession Number (UniProt)	haoA Hydroxylamine oxidoreductase Nitrosomonas europaea Reviewed AL954747 CAD85955.1 Q50925
Gene Protein name Organism Status Accession Number (Genbank) Accession Number (GenPept) Accession Number (UniProt)	haoB Hydroxylamine oxidation protein HaoB Comamonas sp. NLF-7-7 Unreviewed CP042344 QEA14115.1 A0A5B8S0F9
Reference
Authors Title PubMed ID Full research link	van Kessel et al., 2015 Complete nitrification by a single microorganism 26610025 Link
Authors Title PubMed ID Full research link	Kartal et al., 2012 Anammox—Growth Physiology, Cell Biology, and Metabolism 22633060 Link
Authors Title PubMed ID Full research link	Karlsson et al., 2009 Identification of key proteins involved in the anammox reaction 19558586 Link
Authors Title PubMed ID Full research link	Li et al., 2009 The bacterial diversity in an anaerobic ammonium-oxidizing (anammox) reactor community 19403257 Link
Authors Title PubMed ID Full research link	Shimamura et al., 2008 Another multiheme protein, hydroxylamine oxidoreductase, abundantly produced in an anammox bacterium besides the hydrazine-oxidizing enzyme 18397776 Link
Authors Title PubMed ID Full research link	Quan et al., 2008 Diversity of ammonium-oxidizing bacteria in a granular sludge anaerobic ammonium-oxidizing (anammox) reactor 18479446 Link