AE003853.1

Detailed information

Microorganism
Vibrio cholerae O1 biovar eltor str. N16961 (strain ATCC 39315 / El Tor Inaba N16961)

Taxonomy
Phylum : Proteobacteria Class : Gammaproteobacteria Order : Vibrionales Family : Vibrionaceae Genus : Vibrio

Isolation Source
nan

Enzyme Name
Chaperone NapD

Protein Information
Pro_GenBank I.D： AAF96577.1 Length：113 aa Protein FASTA_sequence: Link

Information about Article
Reference：Heidelberg et al., 2000 Title：DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae Pubmed ID：10952301.0 Pubmed link： Link Full research link： Link Abstract：Here we determine the complete genomic sequence of the gram negative, gamma-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins) are located on the large chromosome. In contrast, the small chromosome contains a larger fraction (59%) of hypothetical genes compared with the large chromosome (42%), and also contains many more genes that appear to have origins other than the gamma-Proteobacteria. The small chromosome also carries a gene capture system (the integron island) and host 'addiction' genes that are typically found on plasmids; thus, the small chromosome may have originally been a megaplasmid that was captured by an ancestral Vibrio species. The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.

Reference：Heidelberg et al., 2000
Title：DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Pubmed ID：10952301.0
Pubmed link： Link
Full research link： Link
Abstract：Here we determine the complete genomic sequence of the gram negative, gamma-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins) are located on the large chromosome. In contrast, the small chromosome contains a larger fraction (59%) of hypothetical genes compared with the large chromosome (42%), and also contains many more genes that appear to have origins other than the gamma-Proteobacteria. The small chromosome also carries a gene capture system (the integron island) and host 'addiction' genes that are typically found on plasmids; thus, the small chromosome may have originally been a megaplasmid that was captured by an ancestral Vibrio species. The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.