Biological Nitrogen Removal Database

A manually curated data resource for microbial nitrogen removal


Detailed information

Microorganism

Helicobacter hepaticus (strain ATCC 51449 / 3B1)

Taxonomy

  • Phylum : Proteobacteria
  • Class : Epsilonproteobacteria
  • Order : Campylobacterales
  • Family : Helicobacteraceae
  • Genus : Helicobacter

Isolation Source

nan

Enzyme Name

periplasmic nitrate reductase component NapD

  • Encoding Gene:napD
  • DNA Size:1799146 bp
  • Nucleotide FASTA sequence: Link

  • UniProt I.D: Q7VJT0

Protein Information

  • Pro_GenBank I.D: AAP76760.1

  • Length:119 aa
  • Protein FASTA_sequence: Link

Information about Article

  • Reference:Suerbaum et al., 2003
  • Title:The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
  • Pubmed ID:12810954.0
  • Pubmed link: Link

  • Full research link: Link

  • Abstract:Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized carcinogen. Here we report the complete genome sequence of H. hepaticus ATCC51449. H. hepaticus has a circular chromosome of 1,799,146 base pairs, predicted to encode 1,875 proteins. A total of 938, 953, and 821 proteins have orthologs in H. pylori, Campylobacter jejuni, and both pathogens, respectively. H. hepaticus lacks orthologs of most known H. pylori virulence factors, including adhesins, the VacA cytotoxin, and almost all cag pathogenicity island proteins, but has orthologs of the C. jejuni adhesin PEB1 and the cytolethal distending toxin (CDT). The genome contains a 71-kb genomic island (HHGI1) and several genomic islets whose G+C content differs from the rest of the genome. HHGI1 encodes three basic components of a type IV secretion system and other virulence protein homologs, suggesting a role of HHGI1 in pathogenicity. The genomic variability of H. hepaticus was assessed by comparing the genomes of 12 H. hepaticus strains with the sequenced genome by microarray hybridization. Although five strains, including all those known to have caused liver disease, were indistinguishable from ATCC51449, other strains lacked between 85 and 229 genes, including large parts of HHGI1, demonstrating extensive variation of genome content within the species.