AE014073.1

Detailed information

Microorganism
Shigella flexneri 2a strain 2457T

Taxonomy
Phylum : Proteobacteria Class : Gammaproteobacteria Order : Enterobacterales Family : Enterobacteriaceae Genus : Shigella

Isolation Source
nan

Enzyme Name
Nitrate reductase 1, cytochrome b(NR), gamma subunit

Protein Information
Pro_GenBank I.D： AAP16729.1 Length：225 aa Protein FASTA_sequence: Link

Information about Article
Reference：Wei et al., 2003 Title：Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Pubmed ID：12704152.0 Pubmed link： Link Full research link： Link Abstract：We determined the complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp). Shigella species cause >1 million deaths per year from dysentery and diarrhea and have a lifestyle that is markedly different from those of closely related bacteria, including Escherichia coli. The genome exhibits the backbone and island mosaic structure of E. coli pathogens, albeit with much less horizontally transferred DNA and lacking 357 genes present in E. coli. The strain is distinctive in its large complement of insertion sequences, with several genomic rearrangements mediated by insertion sequences, 12 cryptic prophages, 372 pseudogenes, and 195 S. flexneri-specific genes. The 2457T genome was also compared with that of a recently sequenced S. flexneri 2a strain, 301. Our data are consistent with Shigella being phylogenetically indistinguishable from E. coli. The S. flexneri-specific regions contain many genes that could encode proteins with roles in virulence. Analysis of these will reveal the genetic basis for aspects of this pathogenic organism's distinctive lifestyle that have yet to be explained.

Reference：Wei et al., 2003
Title：Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.
Pubmed ID：12704152.0
Pubmed link： Link
Full research link： Link
Abstract：We determined the complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp). Shigella species cause >1 million deaths per year from dysentery and diarrhea and have a lifestyle that is markedly different from those of closely related bacteria, including Escherichia coli. The genome exhibits the backbone and island mosaic structure of E. coli pathogens, albeit with much less horizontally transferred DNA and lacking 357 genes present in E. coli. The strain is distinctive in its large complement of insertion sequences, with several genomic rearrangements mediated by insertion sequences, 12 cryptic prophages, 372 pseudogenes, and 195 S. flexneri-specific genes. The 2457T genome was also compared with that of a recently sequenced S. flexneri 2a strain, 301. Our data are consistent with Shigella being phylogenetically indistinguishable from E. coli. The S. flexneri-specific regions contain many genes that could encode proteins with roles in virulence. Analysis of these will reveal the genetic basis for aspects of this pathogenic organism's distinctive lifestyle that have yet to be explained.